Nanotechnology delivers An array of opportunities to contribute to biology. Right here I'll current illustrations wherever nanofabrication – a chance to make confined structures with Proportions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:
Our group scientific studies bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our primary desire lies in mobile division, chromatin construction, and spatial Manage.
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2007, initially genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is really a really versatile protein structure; and to start with detection of DNA knots employing nanopores
The coiled-coil with the human Rad50 DNA fix protein consists of unique segments of enhanced flexibility
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling research of nucleosomes and DNA repair proteins to DNA translocation as a result of nanopores. Not long ago his exploration has focused on researching cell division with germs on chip, whilst his ultimate fascination is inside the direction of knowing synthetic cells.
2000, discovery that nanotubes can have extraordinary massive present densities; solved the controversial difficulty of electronic transport as a result of DNA molecules by measurements of insulating conduct at The only molecule amount; and demonstration of the AFM approach for solitary-molecule manipulation of nanotubes
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There was one issue however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of great conductors, which was instead disappointing. We Therefore broadened our check out to try to discover a lot more promising molecules.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Additional not too long ago his research has centered on studying chromatin framework and mobile division with microorganisms on chip, whilst he is likewise trying to finally Construct artificial cells from the bottom up.
Nanoscientist Cees Dekker is really an amiable and flamboyant person who seems Considerably more youthful compared to the sixty two yrs he in fact is – trendy glasses, psychedelic shirt, partaking smile – but not 1 to squander time. He can take his time, but no more than necessary.
2008, first observation of protein-coated DNA translocation through nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; learned a big velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2013, managed shaping of live ceesdekker.net bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes